The 4th International Symposium



The 4th International Symposium for the use of Hyperbaric Oxygenation in the CP and the Brain Child sponsored by the Ocean Hyperbaric Neurologic Center and Dr. Richard A. Neubauer MD was held at the Hyatt Regency Hotel Pier 66 in Fort Lauderdale July 28-31st 2004.

This was undoubtedly the most successful conference ever held on the topic of hyperbaric oxygen, alternative approaches and pediatric neurology. We hosted about 600 attendees including caregivers, parents, therapist and doctors from around the world.

Nearly 50 international speakers (mostly MDs) joined us to share their experience and expertise regarding the positive effects of the use of oxygen under greater than atmospheric pressure in the treatment of cerebral palsy and pediatric neurology.

Brief summaries of the presentations follow. A complete book of the abstracts of all of the presentations is available for $25.00 (including shipping &handling) by calling our office at 1-800-552-0255. The complete abstracts of the Symposium will include all addresses, phone numbers and e-mails of the presenting physicians. Videos will also be available of the entire conference or single presentations shortly.

Dr. Rashid Buttar, D.O., FAAPM, FACAM, FAAIM
Broken Pathway in Autism: The Mercury Poisoning of our Children and Their Inability to Detoxify

This talk not only pointed out that the common denominators in chronic neurodegenerative disease are of decreased vascular supply and/or accumulation of heavy metals, specifically, mercury. The forward thinking Dr. Buttar has now developed a new and simple transdermal type of chelation therapy, which is a medical, break through in the treatment of heavy metal (mercury) toxicity. The relationship between heavy metal and autism, as well as in much neurologic pathology, including Alzheimer’s disease cannot be overlooked.

Dr. Andrew W. Campbell MD
Medical Director, Center for Immune, Environmental and Toxic Disorders
Neuro Imaging of the Brains of Children Chronically Exposed to Toxigenic Molds: The Possible Role of Hyperbaric Oxygenation Therapy in Rapid Recovery

This presentation reported the outcomes of neuroimaging of pediatric chronic exposure to toxigenic molds and mycotoxins and clarified that hyperbaric oxygen therapy may be useful in rapid recovery of such patients. He reports that these molds and toxins have shown to have damaging neurological effects in children and might be responsible for several neurobehavioral conditions such as attention and learning deficits and hyperactivity disorders in children. Dr. Campbell also noted the relationship of vaccination to cerebral palsy and the brain-injured child. He also states/reiterates that the instance of onset of CP and autism following vaccination is very possibly related to mercury toxicity.

Dr. Ivan Chavdarov, MD, Ph.D.
The Place of Hyperbaric Oxygenation in The Treatment Strategy For Children with Cerebral Palsy and Related Disorders

Dr. Chavdarov employs a true multi-disciplinary approach to “CP at risk” and “fixed CP” patients in a very large center in Bulgaria. He uses a variety of approaches specific to the child’s condition including physio-, logo-, Montessori-therapy, HBO, low frequency impulse magnetic field, TENS, thermo-, hydro- and drug therapy with excellent long term follow-up. He also shows that HBO has an important place in the treatment of children with other problems such as ADHD, mental retardation, dysphasia and other behavioral disorders.

Gao Chunjin
Effects of Hyperbaric Oxygen Therapy on Platelet Membrane Glycoprotein In Patients with Ischemic Stroke

Although not reporting on a pediatric population Dr. Chunjin demonstrated that hyperbaric oxygenation had a positive effect in reducing platelet adherence in patients with ischemic thrombotic stroke. This finding, however, has clear and positive implications in other neurologic pathologies.

David Denton Davis, M.D
The Bioconversion of Periodic Table Class VB Elements Into Their Gas Forms as a Possible Cause of Childhood Death and Neurological Disability

This was an extremely interesting talk and showed clearly that the cause of SIDS (Sudden Infant Death Syndrome) may be due to heavy metal poisons (antimony and arsenic) causing toxic mold in a baby’s mattress. This problem can be avoided with a $10 mattress cover, or ameliorated by HBOT and chelation.

Jose L. Diaz Barboza, M.D.,
Medical Director, Medicina Hiperbarica de Mexico
Frank J. Morales, M.D.
Arturo Landeros, M.D.
Jose Garibay-Ubay, M.D.

Designs of a New Protocol: The Combination of HBO, Stem Cell Therapy, And the Application of Omentum For Spinal Cord Injuries

This opens a fascinating new arena for the combination of HBO and autologous stem cell therapy combined with the very valuable work of Dr. Harry Goldsmith of carefully overlaying the omentum for spinal cord injuries. (This is also highly effective in Alzheimer’s disease and has shown to extensively reduce plaques and aluminum.)

Giuseppina Feingold, M.D.
Alternative Approaches to Rehabilitation

This mother of a CP patient is also a pediatrician. She discussed the necessity of alternative approaches to neuro-rehabilitation for CP and the brain-injured child. Her main themes were Sensory Learning, intensive suit therapy and integrative manual therapy.

Ignatio Fojgel, M.D.
Physiological Bases, Indications and Protocols of the Low, Mild and Ultra Low Hyperbaric Treatment Modalities

Dr. Fojgel presents a fascinating discussion of the official definition of hyperbaric oxygen therapy, gradual dosage of the same, as well as hypobaric medicine and gas concentrations other than 100% oxygen in the clinical applications of baromedicine. Besides the above, Dr. Fojgel also revisited his previous talk where he pointed out the dangers of brain-injured children flying on commercial airplanes and the atmospheric pressures and oxygen contents at 39,000 feet.

Charles Golden, Ph.D.
Lorie Greene, Zarabeth Golden, Brandon Korman
The Effects of Hyperbaric Oxygenation on Metabolic and Cognitive Changes in Brain-Injured Patients
Aging and HBO

Dr. Golden, et al. present controlled neuropsychological studies that prove strongly supportive of the use of HBOT as a treatment for lessening the neurological and cognitive impact of chronic brain injury indicating that HBOT can be an effective aid in ameliorating the neuropsychological and physiological effects of a type of brain injury heretofore believed to be untreatable.

Harry S. Goldsmith, M.D.
Omentum Transposition in the Treatment of Cerebral Palsy

Omental transposition involves the elongation and placement of the omentum (a specialized membranous tissue located in the abdominal cavity) directly on the surface of the brain. Although hyperbaric oxygenation has the ability to increase cerebral blood flow, there is a limit to the volume of CBF that HBO treatment can deliver which can be enhanced by omental transposition. Omental transposition has been confirmed by 5-year follow up to significantly increase the blood flow to the brain on a yearly basis. A study of the effects of HBO and omental transposition is proposed

Hyperbaric Oxygen Delivery Systems

Dr. Gottlieb pointed out the various methods of the administration of hyperbaric oxygenation, explaining the differences, similarities, pros and cons of the multi-place chamber vs. the monoplace chamber. He briefly touched on the subject of the new, as yet unproven, portable hyperbaric chambers.

Brain Injury, Cerebral Palsy, and Autism: Using Medications to Improve Blood Flow to the Injury

Dr. Hammesfahr’s careful use of vasodilators and his excellent results have resulted in a proposal for Nobel Prize nomination. This is extremely important information and its applications are synergistic with hyperbaric oxygen therapy.

Hyperbaric Oxygen Therapy in the Treatment of Autism

This was a very interesting talk on the correlation of three-dimensional reconstruction of SPECT brain imaging to the clinical status and the positive effects of hyperbaric oxygen in the autistic child. Five cases were selected for presentation suggesting an underlying pathophysiological process in chronic neurological conditions and the generic, drug like response to low pressure HBOT.

Children’s International Group HBO Experience

Dr. Hernandez has been on nationwide television because of his excellent work in the use of hyperbaric oxygenation in a terminal case of acute meningeal meningitis whereby no other therapy would have been effective or available. Here he has presented the group’s experience with 23 children with catastrophic brain injury showing dramatic improvement with HBO.

Neuromed and Neurotox Association
Mild HBO Treatment as an Immune Modulator

Dr. Gunnar Heuser stressed the use of hyperbaric oxygenation and its effect on the immune system in patients with toxic chemical exposure - a most important observation.

PHILIP B. JAMES, M.B., Ch.B., D.I.H., Ph.D., F.F.O.M.
Professor of Hyperbaric Medicine
The Scientific Basis of Brain Repair

Dr. James provided unequivocal evidence that stem cells from bone marrow can migrate from the circulation across the blood-brain barrier into the tissues of the brain and gave great detail as to the delivery of oxygen hyperbarically to enhance ATP production in the cells for recovery. He also spoke of the critical fallacy of retrolentil fibroplasias in the pediatric population that was expounded upon for years - a tragedy.

Mechanisms of Action of Surplus Pressure in Barochamber in Treatment of Neurodegenerations

Dr. Kazantzeva pointed out the remarkable changes that take place in neurodegenerations with pressures as low as 1.0 in combination with cyclosporine A. This opens up a whole field. Investigations are continuing not only in the brain-injured child, but also in multiple neurodegenerative diseases, such as Alzheimer’s, MS, ALS and stroke.

Doctor, Why Does My Child Have Cerebral Palsy?

Dr. Lacey pointed out that cerebral palsy is purely a “wastebasket” term. The etiology may encompass many, many factors. CP may be near drowning, shaken baby syndrome as well as the prenatal and post-natal causes; including early exposure in utero to toxins, infections, and “programming defects” (e.g., chromosomal, enzyme deficiencies) which cause interruption of the normal early development of the brain, causing a permanent alteration in muscle tone.

HBO in the Treatment of Chronic Neurological Conditions in Children: A Longitudinal Study

Dr. Marois originally participated in a break-through study showing the positive effects not only of 1.75 ATA of hyperbaric oxygenation, but also, a good result in the “so-called” control of 1.35 air. There was a significant difference in the rapidity and the severity responses at the higher dose of 100% oxygen, but the fact that the pressurized air was of some avail was noteworthy. Here he presents the results in over 100 children treated with 1.5 ATA, 100% oxygen with significant improvement in gross motor function (>65%) and >80% in other areas such as cognition, communication, fine motor abilities, and play. He also presents children with other types of neurological conditions including autism, Down’s syndrome, developmental delays, traumatic brain injury, etc. with persistent positive changes following treatment with HBO.

The Importance of Hyperbaric Oxygen Therapy and Methods of Documenting Response
USA & Canada

Dr. Maxfield discusses the use of SPECT brain scan to document the pattern of brain function and neurological response to hyperbaric oxygen, and discusses some of the problems with interpretation of the same. He also discusses PET scanning, the development of a tracer to diagnose early Alzheimer’s and MRI spectroscopy for MS and other neurological conditions. He also advocates the simple use of still pictures and videotaping as documentation of response to HBOT, providing exemplary cases.

Hyperbaric Medicine as Supportive Therapy in Oncology

Hyperbaric oxygen as a supportive therapy in oncology opens up a whole new branch, which was also elucidated upon by Dr. Shantha.
Dr. Maxfield discusses the benefits of HBO in the morbidity of chemotherapy extravasation and the treatment of anemia of cancer synergistically with erythoropoietin. Hyperbaric oxygenation is routinely used in Japan prior to radiation for brain tumors with a 50% increase in survival and is used in other countries to enhance the effectiveness of chemotherapy.

HBO and Heavy Metal Detoxification in Muscular Dystrophy: An Ongoing Study
USA & Mexico

Dr. Morales demonstrates the high incidence of heavy metal toxicity in MD, and that when treated appropriately will show the increased beneficial effects of HBOT when specialized heavy metal chelates are utilized in an appropriate protocol. He concludes that the use of hyperbaric oxygen therapy for Duchenne dystrophy and other autoimmune and degenerative disorders is certainly establishing precedent, due to its notable and beneficial effects. Although this was just one study, it is referable to many cases of Duchenne muscular dystrophy..

Update on the Ongoing “UDAAN” Multimode, Including Hyperbaric Oxygenation and Early Medical Intervention Therapy for Small Children with Moderate to Severe Cerebral Palsy

This was an excellent controlled study comparing standard intensive therapy to the same plus adjuvant therapy with HBOT plus CP-specific acupuncture, ayurvedic neuro-resotative therapy and nerve block (where required),. Dr. Mukherjee compared their long-term results to the shorter CP/HBO studies done in Canada and showed that the long-term persistent results are extremely important. Many of the HBOT group children achieved ADL within one-half to one year.

HBO in Acute Neurologic Injury: Current Investigations

Dr. Mychaskiw indicated that actually in CP/brain injured child or any type of acute ischemia, cerebral edema, with increased lactate that it is essential to use hyperbaric oxygenation as soon as possible when available. He also focused on the therapeutic windows of HBO in brain injuries and the potential mechanisms of HBO in neuroprotection and explored the discrepancies of experimental and clinical observations.

Hyperbaric Oxygenation – An Overview
A Brief Introduction to Genetics as it Applies to the Use of Hyperbaric Oxygenation in Mitochondrial Diseases

This was first presentation ever of the highly positive results of the use of hyperbaric oxygenation in mitochondrial cytopahies, opening up a whole new frontier for the field of HBO for investigation of errors of inborn metabolism and genetic disease.

LEAH NOF, Ph.D., M.S.,P.T.
Benefits of Body Weight Support Treadmill Gait training for Children and Adults with Neurological Pathology

Dr. Nof stressed the profound importance of appropriate gait training and muscle utilization. Ray Cralle, physical therapy, Delray Beach, FL, also spoke of these insights. They stressed the importance of appropriate PT, OT in the child with cerebral palsy and the marked reduction of spasticity that occurs with therapy alone. However, when combined with hyperbaric oxygenation, they stressed, the results were compounded.

Stroke Pathology using HBO and EDTA Chelation Therapy Between the Beginning until the Sixth Month of Pathology

Dr. Olszewer is one of the leaders of the “orthomolecular” movement, as non-conventional medicine is in called Brazil, he was one of the groundbreaking doctors in the use of DMSO for arthritis. He now combines EDTA, a chelation therapy known to remove lead (heavy metal toxicity) and which has been shown to improve circulation by de-calcifying the arteries in the treatment of stroke patients. He reports, as well on his results in a three-year follow-up of hyperbaric oxygen in cerebral palsy demonstrating the persistence of the improvements without further hyperbaric oxygen treatments, although reporting slightly better results using one week each month maintenance.

Pathophysiology of Acute Hypoxic Brain Injury: Role of HBO as a Neuroprotector

Dr. Sanchez now has long term follow-up on neonates taken from the delivery room directly to the hyperbaric chamber showing that one hour of hyperbaric oxygenation is capable of turning a child’s life around with early neuroprotection. He stressed that the sooner the intervention, the better, to interrupt the inflammatory cascade of neuronal damage that depends on the mitochondrial capability of maintaining ATP production. Among other findings, his results prove that HBO can positively modify tissue levels of ATP.

T.R. SHANTHA, M.D., Ph.D., F.A.C.A., D.A.B.A., D.A.P.A.P., EX.FZS, F.R.M.S.
Oxygen Therapies: Hyperbaric Oxygen (HBO-HBA), Hydrogen Peroxide (H2O2), and Ozone (O3) Therapies to Treat Cancers and Other Diseases

Dr. Shantha presented an excellent multi-disciplinary approach to cancer, a disease that is so frequently looked upon with such a frightening and pessimistic outlook in the United States. The primary focus of the approach is based on the oxidative therapies, with the main protocol encompassing and focusing upon hyperbaric oxygen. As the early work of Dr. Koch, who was ultimately condemned by the FDA, and the research resulting in the 1930’s Nobel prize to Otto Warburg both showing that cancer was a result of impaired oxidation processes, the results from Dr. Shantha, may once again revolutionize cancer treatments.

A Pilot Study of Umbilical Cord Derived Stem Cell Therapy for Cerebral Palsy

Dr. Steenblock presents the results of seven cerebral palsy patients treated with umbilical cord-derived stem cells showing slight to moderate improvements within the first month post-treatment in a variety of functions even in subjects where other therapies, including hyperbaric oxygen had reached a plateau in terms of clinical benefit.

Quantification of Neurocognitive Changes Before and After Hyperbaric Oxygen Therapy in a Child with Cerebral Palsy

This was an excellent review of the neurocognitive changes before and after hyperbaric oxygenation in a child with CP. The fact that this has such a profound effect on many of the patients’ cognitive function is an important observation. He found significant improvements in seven modules of computer-administered test battery including memory, reaction time and visual-motor speed outcome measurements. H concludes that hyperbaric oxygenation should be the treatment of choice in all cases of cerebral palsy even in treatment is delayed by years.

The Present and Near Future of Functional Imaging of Brain “Injury”

Dr. Uszler, again presented substantiation of non-invasive brain imaging with SPECT and PET to document the effects of hyperbaric oxygenation. Dr. Uszler also brought up a new technique calling for co-registration whereby the SPECT scan may be overlaid on the MRI for a much more complete analysis of its function. He also spoke of a forthcoming technology called fMRI, which is being developed and analyzed in its ability to contribute brain function information.

HBO in Cerebral Hypoxic Lesions Caused by Cerebrovascular Obstructions: Experimental and Clinical Investigations

Dr. Wassmann from Germany was the first to show the proper dose of hyperbaric oxygenation to be from 1.25-1.5 ATA 100% oxygen. In his definitive studies on cerebral energetics in the 1980s he clearly demonstrated that approaching 2 ATA in the injured brain was ineffective for brain repair and quite possibly deleterious. His experimental studies presented here give evidence that cerebral ischemia is better tolerated under HBO, and revealed this as a safe and adjuvant therapeutic method in the treatment of “cerebral energy crisis”.

Transient Exposure to HBO is a Safe and Effective Therapy for Neonates: Experimental Evidences

Dr. Zhang noted that one of the major effects of HBO at a molecular level is its anti-apoptotic (programmed cell death) action which saves the dying cells and restores their physiological functions, thus again stressing that the earlier the exposure of neonates to hyperbaric oxygenation, the better the results. He also demonstrated a brain weight preservation effect of HBO and a prevention of DNA fragmentation. This was shown in the experimental animal. Again, Dr. Zhang ruled out the fallacy of retrolentil fibroplasia finding of no signs of neovascularization, abnormalities in structure of the retina or changes in protein expression after hyperoxia exposure.

Clinical Analysis of Two Hundred and Forty-Four Inpatients with ACOP

The fact that the United States does not cover this with any type of insurance may prove to look very embarrassing by the hundred’s of cases that are successfully treated in China. They have had records for a number of years. The other thing noted by Dr. Zhuo was that the hospitalization time is significantly cut down with the addition of hyperbaric oxygenation to the therapy.